The Müller Lab

Neural
Resilience
Across Scales

The brain stabilizes its function to withstand perturbations, including pathological challenges.

We seek to unravel molecular and cellular mechanisms that underlie this resilience.

Research Questions

We employ a broad and integrative set of approaches, ranging from electrophysiology and super-resolution microscopy to animal behavior, and model systems spanning Drosophila to human iPSC-derived neurons, to tackle the following questions:

Homeostatic control of synaptic nano-architecture and function

Which mechanisms regulate synaptic nano-architecture and function during homeostatic plasticity?

Homeostatic compensation and disease in human neuronal systems

Which homeostatic mechanisms stabilize human neurons, and how do they relate to disease?

Synaptic homeostasis and sleep

What is the relationship between synaptic homeostasis and sleep behavior?

Updates from the lab

general•May 6, 2026

A wonderful visit from Graeme Davis

We had the pleasure of hosting Graeme Davis from UCSF. His insightful lecture on synaptic homeostasis, engaging discussions, and lovely stories made for a truly inspiring and fun visit. We loved having him here!

team•February 22, 2026

We had the first champagne of the year thanks to Alena's birthday!

general•February 22, 2026

The data bell rang the second time this year already!

For Marta's preliminary ephys data (TDP-43 project). Congrats!

NeuralResilienceAcross Scales